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6-APB, also known as 6-(2-aminopropyl)benzofuran, is a benzofuran-class research chemical that has gained attention in scientific environments for its structural similarity to entactogenic phenethylamines. First synthesized in the early 1990s, 6-APB is often studied as a potential analogue to MDMA, with researchers exploring its serotonergic and adrenergic activity.
Chemical Background
- Chemical Class: Benzofuran
- IUPAC Name: 1-(benzofuran-6-yl)propan-2-amine
- Molecular Formula: C11H13NO
- Molar Mass: 175.23 g/mol
6-APB exists in several research formats, including powder, crystal, or pellet form, depending on supplier availability. Scientific analyses typically focus on structure–activity relationships (SAR), binding affinity, and metabolic pathways.
Applications in Research
Academic interest in 6-APB includes:
- Behavioral neuroscience
- Pharmacodynamics and pharmacokinetics
- Comparative analysis to classical entactogens
- Toxicology and metabolic studies
Due to its unique benzofuran ring and active amine chain, 6-APB is used as a model compound in studies exploring:
- Structure modification
- Transporter affinity variations
- Monoamine system interactions
Storage and Handling
For laboratory environments, typical guidance includes:
- Cool, dry, light-protected storage
- Proper labeling and hazard communication
- Use of PPE (gloves, masks, goggles)
- Secure, access-controlled facility protocols









